Wednesday, October 23, 2013

Day 17: The Migration of Humans Part 1



In the video called "Journey of Man" we learned that a "time machine" is essentially DNA that can help us look back into history. All of our ancestors originated in Africa around 50,000 years ago and then migrated. The tribe that is still present today that is the most genetically similar to our ancestors is the San tribe men in the Kalahari Desert. They display many of the phenotypes that races today have. A genetic marker is a mutation in chromosomes and DNA that took place in one individual and was passed down and inherited. This shows us where all our ancestors split and started having really different mutations. After starting the migration from Africa, the next place we found evidence of our ancestors being present was Australia. This is a problem because this would have been a huge distance to cover and we think that our ancestors walked along the coast to reach Australia. The problem is that there was a lot more land back then due to the ice caps being large and still very frozen. So the route they took is now underwater. Essentially though we are all descendants of early Africans. This poses the question of: Does race really exist? If we were all related to each other 50,000 years ago and our pretty genetically similar than how did race develop? The answer is in the genes of races. Scientists decided to collect data from alus. Alus are short pieces of DNA that are similar in sequence to one another. This is a class of polymorphisms. Polymorphisms are in genetics the presence of variation in a population upon which natural selection can operate. Aluses once they replicate, they can spilt and then reinsert itself into a chromosome, and once inserted those alus will become permanent for a very long time and be inherited. These alus can be analyzed and provide information for people sharing a common ancestor. Scientists took a bunch of alus data from different races and then blindly, without knowing what race corresponded to what organized them into four groups. When they “applied” the labels and discovered what sample was from what race then they saw that they sorted them by similarities and most were from the same area of the world. This has been conducted several times, all yielding similar results that we can sort data into five major groups. These groups are; Sub-Saharan Africans, Northern Africans/ Europeans, West of the Himalayas Asians, East Asians, and Native Americans.  It is easier to distinguish between people from isolated and very separated parts of the world than analysis of people in a population of one country. The one country population in comparison would be very muddled. Natural selection in evolution sets up our standards of what race is. We usually distinguish race based on pigmentation of skin that has been caused by natural selection. Africans and Aborigines in Australia may have the same pigmentation of the skin because it protects them better from the harsh sun in those areas but their alus polymorphisms are very different.. The questions this brings to light is that in society should we change things like the race questions on standardized tests to be more scientifically correct and only state 5 clear races? Should we then change the norm for referring to races based on something other than phenotypes? Polymorphisms also can have beneficial aspects such as how people with one copy of a sickle cell in the Mediterranean area can be resistant to malaria. If such things are possible can we genetically engineer to make all individuals contain beneficial polymorphisms in their genes? 

We will continue watching this video next class time.

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